A cellulose derivative film having high optical isotropy over the whole visible region and high durability against high temperature and humidity conditions is provided. The film contains a cellulose derivative having a substituent the polarizability anisotropy Δα (=αx−(αy+αz)/2) of which is 2.5×10−24 cm3 or more, and the film has an in-plane retardation Re and a thickness direction retardation Rth satisfying the respective inequalities: |Rth(589)|≦25 nm and |Re(589)|≦10 nm. Also provided are an optical compensation film, a polarizing plate, and a liquid crystal device that use the cellulose derivative film and exhibit excellent viewing angle characteristics and durability.