发明授权
- 专利标题： Arylsulfonamide-based matrix metalloprotease inhibitors
- 专利标题（中）： 基于芳基磺酰胺的基质金属蛋白酶抑制剂
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申请号： US12933988申请日： 2009-03-23
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公开(公告)号： US08222424B2公开(公告)日： 2012-07-17
- 发明人: Claus Ehrhardt , Leslie Wighton McQuire , Pascal Rigollier , Olivier Rogel , Michael Shultz , Ruben Alberto Tommasi
- 申请人： Claus Ehrhardt , Leslie Wighton McQuire , Pascal Rigollier , Olivier Rogel , Michael Shultz , Ruben Alberto Tommasi
- 申请人地址： CH Basel
- 专利权人： Novartis AG
- 当前专利权人： Novartis AG
- 当前专利权人地址： CH Basel
- 代理商 Sophie Binet Cross
- 国际申请： PCT/EP2009/053390 WO 20090323
- 国际公布： WO2009/118292 WO 20091001
- 主分类号： C07D231/54
- IPC分类号： C07D231/54 ; A61K31/416
摘要：
The present invention provides a compound of formula (I): said compound is inhibitor of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP-13, and thus can be employed for the treatment of a disorder or disease characterized by abnormal activity of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP-13. Accordingly, the compound of formula (I) can be used in treatment of disorders or diseases mediated by MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12, and/or MMP-13. Finally, the present invention also provides a pharmaceutical composition.
公开/授权文献
- US20110014186A1 ARYLSULFONAMIDE-BASED MATRIX METALLOPROTEASE INHIBITORS 公开/授权日：2011-01-20
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