发明授权
- 专利标题： Oligodeoxynucleotide and its use to induce an immune response
- 专利标题（中）： 寡脱氧核苷酸及其用于诱导免疫反应的用途
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申请号： US13104918申请日： 2011-05-10
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公开(公告)号： US08227446B2公开(公告)日： 2012-07-24
- 发明人: Dennis Klinman , Daniela Verthelyi , Ken Ishii , James J. Mond , Mayda Gursel
- 申请人： Dennis Klinman , Daniela Verthelyi , Ken Ishii , James J. Mond , Mayda Gursel
- 申请人地址： US DC Washington
- 专利权人： The United States of America, as represented by the Secretary of the Department of Health and Human Services
- 当前专利权人： The United States of America, as represented by the Secretary of the Department of Health and Human Services
- 当前专利权人地址： US DC Washington
- 代理机构： Klarquist Sparkman, LLP
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K39/38 ; A61K45/00 ; A61K47/00 ; A61K31/70 ; A61K9/127 ; A01N43/04
摘要：
D type CpG oligodeoxynucleotides are provided herein that include a sequence represented by the following formula: 5′X1X2X3Pu1Py2CpGPu3Py4X4X5X6(W)M(G)N-3′ wherein the central CpG motif is unmethylated, Pu is a purine nucleotide, Py is a pyrimidine nucleotide, X and W are any nucleotide, M is any integer from 0 to 10, and N is any integer from 4 to 10. Methods of using these oligodeoxynucleotides to induce an immune response are provided.
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