发明授权
- 专利标题: Indazole derivative having spiro ring structure in side chain
- 专利标题(中): 侧链具有螺环结构的吲唑衍生物
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申请号: US12227890申请日: 2007-06-08
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公开(公告)号: US08227480B2公开(公告)日: 2012-07-24
- 发明人: Masahiko Hagihara , Yasunori Tsuzaki , Ken-ichi Komori , Hiroshi Nishida , Kazutaka Kido , Tomokazu Fujimoto , Takeshi Matsugi , Atsushi Shimazaki
- 申请人: Masahiko Hagihara , Yasunori Tsuzaki , Ken-ichi Komori , Hiroshi Nishida , Kazutaka Kido , Tomokazu Fujimoto , Takeshi Matsugi , Atsushi Shimazaki
- 申请人地址: JP Yamaguchi JP Osaka
- 专利权人: Ube Industries, Ltd.,Santen Pharmaceutical Co., Ltd.
- 当前专利权人: Ube Industries, Ltd.,Santen Pharmaceutical Co., Ltd.
- 当前专利权人地址: JP Yamaguchi JP Osaka
- 代理机构: Holtz, Holtz, Goodman & Chick, P.C.
- 优先权: JP2006-159501 20060608
- 国际申请: PCT/JP2007/061598 WO 20070608
- 国际公布: WO2007/142323 WO 20071213
- 主分类号: A01N43/42
- IPC分类号: A01N43/42 ; A61K31/44 ; C07D211/00 ; C07D213/00 ; C07D215/00 ; C07D217/00 ; C07D219/00 ; C07D221/00
摘要:
An object of the present invention is to create a novel indazole derivative having a spiro ring structure in a side chain, which is useful as a pharmaceutical, and to find a new pharmacological activity of the derivative. The present invention compound is represented by the general formula [I] and has an excellent Rho kinase inhibitory activity. In the formula, the ring X represents a benzene ring or a pyridine ring; R1 and R2 represent halogen, H, OH, alkoxy, cycloalkyloxy, aryloxy, alkyl, cycloalkyl or the like; R3 represents halogen, H or the like; R4 and R5 represent halogen, H or the like; R6 and R7 represent H, alkyl or the like; and m, n, p and q represent an integer of 0 to 3. In this connection, each group may have a substituent.
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