发明授权
US08227481B2 Substituted piperidine spiro pyrrolidinone and piperidinone, preparation and therapeutic use thereof 有权
取代的哌啶螺吡咯烷酮和哌啶酮,其制备和治疗用途

  • 专利标题: Substituted piperidine spiro pyrrolidinone and piperidinone, preparation and therapeutic use thereof
  • 专利标题(中): 取代的哌啶螺吡咯烷酮和哌啶酮,其制备和治疗用途
  • 申请号: US13151946
    申请日: 2011-06-02
  • 公开(公告)号: US08227481B2
    公开(公告)日: 2012-07-24
  • 发明人: Zhongli GaoDaniel HallRyan Hartung
  • 申请人: Zhongli GaoDaniel HallRyan Hartung
  • 申请人地址: FR Paris
  • 专利权人: Sanofi
  • 当前专利权人: Sanofi
  • 当前专利权人地址: FR Paris
  • 代理商 Kelly L. Bender
  • 优先权: FR0955431 20090731
  • 主分类号: C07D401/04
  • IPC分类号: C07D401/04 A61K31/438
Substituted piperidine spiro pyrrolidinone and piperidinone, preparation and therapeutic use thereof
摘要:
The present disclosure relates to a series of substituted N-phenyl-bipyrrolidine carboxamides of formula (I). wherein R1, R2, R3, m, n and p are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, methods of preparation of substituted N-phenyl-bipyrrolidine carboxamides and intermediates therefor are disclosed.
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