发明授权
- 专利标题: 5-membered nitrogen containing heterocyclic derivatives and pharmaceutical compositions comprising the same
- 专利标题(中): 5元含氮杂环衍生物和包含它们的药物组合物
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申请号: US12595437申请日: 2008-04-10
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公开(公告)号: US08227500B2公开(公告)日: 2012-07-24
- 发明人: Kazuo Shimizu , Yasushi Takigawa , Hideki Fujikura , Masato Iizuka , Masahiro Hiratochi , Norihiko Kikuchi
- 申请人: Kazuo Shimizu , Yasushi Takigawa , Hideki Fujikura , Masato Iizuka , Masahiro Hiratochi , Norihiko Kikuchi
- 申请人地址: JP Matsumoto-shi
- 专利权人: Kissei Pharmaceutical Co., Ltd.
- 当前专利权人: Kissei Pharmaceutical Co., Ltd.
- 当前专利权人地址: JP Matsumoto-shi
- 代理机构: Westerman, Hattori, Daniels & Adrian, LLP
- 优先权: JP2007-104094 20070411
- 国际申请: PCT/JP2008/057093 WO 20080410
- 国际公布: WO2008/126899 WO 20081023
- 主分类号: A61K31/405
- IPC分类号: A61K31/405 ; C07D207/00
摘要:
The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal serum uric acid level which has a uricosuric activity or the like. The present invention relates to 5-membered heterocyclic derivatives represented by the following general formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, prodrugs thereof, or salts thereof. In the formula (I), T represents nitro, cyano and the like; ring J represents aryl or heteroaryl; Q represents carboxy, 5-tetazolyl and the like; Y represents H, OH, NH2, halogen, haloalkyl and the like; X1 and X2 independently represent CR2 or N; R2 represents H, alkyl and the like; R1 represents halogen, cyano, haloalkyl, A-D-E-G-L-M, -N(-D-L-M)2 and the like, in the formula, A represents a single bond, O, S and the like; D, G and M independently represent optionally substituted alkylene, cycloalkylene, heterocycloalkylene, arylene, heteroarylene and the like; E and L independently represent a single bond, O, S, COO, SO2 and the like.
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