Adjustable holding systems, as well as methods of using, may include a fixed base adapted for use on a work surface, the fixed base having a rear actuated clamp assembly secured thereto. Other systems and methods may include one or more bases adapted for use on a work surface; and a guide assembly removably securable to the one or more bases, wherein the guide assembly provides infinite vertical adjustability which can be retained without clamping. Yet other systems and methods may include a portable base securable to a work surface, the portable base having a portable base opening.