A method of forming a medical wrap including a flexible, sheet-form substrate with a discrete medical function delivery region having a surface adapted to be placed against a patient's skin to provide a desired medical effect. The substrate carries a field of fibers exposed for engagement by an array of fastener elements. The fastener elements each have a respective stem extending integrally from a band of resin extending along the substrate. The fastener elements are constructed to snag the exposed fibers when the substrate is wrapped about a patient in an overlapping manner, securing the wrap about the patient with the medical function delivery region in a desired position. The wrap is configured for use as a hot or cold pack, a medical dressing, or drug delivery device.