发明授权
- 专利标题: Inhibitors of the interaction between MDM2 and P53
- 专利标题(中): MDM2与P53相互作用的抑制剂
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申请号: US12293545申请日: 2007-03-19
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公开(公告)号: US08232298B2公开(公告)日: 2012-07-31
- 发明人: Jean Fernand Armand Lacrampe , Christophe Meyer , Bruno Schoentjes , Delphine Yvonne Raymonde Lardeau , Alain Philippe Poncelet , Luc Van Hijfte
- 申请人: Jean Fernand Armand Lacrampe , Christophe Meyer , Bruno Schoentjes , Delphine Yvonne Raymonde Lardeau , Alain Philippe Poncelet , Luc Van Hijfte
- 申请人地址: BE Beerse
- 专利权人: Janssen Pharmaceutica N.V.
- 当前专利权人: Janssen Pharmaceutica N.V.
- 当前专利权人地址: BE Beerse
- 代理商 Rajiv S. Shah
- 优先权: EP06111531 20060322
- 国际申请: PCT/EP2007/052579 WO 20070319
- 国际公布: WO2007/107543 WO 20070927
- 主分类号: A61K31/44
- IPC分类号: A61K31/44 ; C07D421/00
摘要:
The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, m, p, s, t, R1, R2, A and Z have defined meanings.
公开/授权文献
- US20090149493A1 INHIBITORS OF THE INTERACTION BETWEEN MDM2 AND P53 公开/授权日:2009-06-11