发明授权
US08232408B2 Crystalline 1-(3-fluorophenyl)-5-methyl-2-(1H)pyridone, the preparation methods, compositions and applications thereof
有权
结晶1-（3-氟苯基）-5-甲基-2-（1H）吡啶酮，其制备方法，组合物及应用
- 专利标题： Crystalline 1-(3-fluorophenyl)-5-methyl-2-(1H)pyridone, the preparation methods, compositions and applications thereof
- 专利标题（中）： 结晶1-（3-氟苯基）-5-甲基-2-（1H）吡啶酮，其制备方法，组合物及应用
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申请号： US12920320申请日： 2009-03-10
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公开(公告)号： US08232408B2公开(公告)日： 2012-07-31
- 发明人: Jiamei Chen , Tongbu Lu , Song Chen , Jinghui Cai , Zhaolin Fu , Zhe He , Xuefeng Wang , Chaozhi Wang , Yonge Liu , Lijian Tao , Gaoyun Hu
- 申请人： Jiamei Chen , Tongbu Lu , Song Chen , Jinghui Cai , Zhaolin Fu , Zhe He , Xuefeng Wang , Chaozhi Wang , Yonge Liu , Lijian Tao , Gaoyun Hu
- 申请人地址： CN Dongyangguang Hi-tech Park, Shang Sha, Chang An Town, Dongguan, Guangdong
- 专利权人： Sunshine Lake Pharma Co., Ltd.
- 当前专利权人： Sunshine Lake Pharma Co., Ltd.
- 当前专利权人地址： CN Dongyangguang Hi-tech Park, Shang Sha, Chang An Town, Dongguan, Guangdong
- 代理机构： Squire Sanders
- 代理商 Kam W. Law
- 优先权： CN200810101643 20080310
- 国际申请： PCT/CN2009/000256 WO 20090310
- 国际公布： WO2009/111947 WO 20090917
- 主分类号： C07D211/72
- IPC分类号： C07D211/72 ; A61K31/44
摘要：
Crystalline pyridone compound, which is the white needle crystal containing no water and other crystallization solvents. Its unit cell belongs to monoclinic system and has space group of P21/n, wherein a=3.8512(2), b=20.2535(12), c=12.1628(6) Å, β=92.850(5)° and crystal cell volume V=947.53(9) Å3. Pyridone compound crystal of this form has the needed properties for preparing or making treatment compositions in large scale. It can be used for treating organs fibrosis of liver, kidney, lung and etc. and reducing skin scars.
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