发明授权
US08232413B2 Process for the production of a crystalline glucagon receptor antagonist compound
有权
制备结晶胰高血糖素受体拮抗剂化合物的方法
- 专利标题： Process for the production of a crystalline glucagon receptor antagonist compound
- 专利标题（中）： 制备结晶胰高血糖素受体拮抗剂化合物的方法
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申请号： US12675990申请日： 2008-09-08
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公开(公告)号： US08232413B2公开(公告)日： 2012-07-31
- 发明人: Benjamin M. Cohen , Daniel J. Kumke , Lushi Tan , Aaron S. Cote
- 申请人： Benjamin M. Cohen , Daniel J. Kumke , Lushi Tan , Aaron S. Cote
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Anna L. Cocuzzo; Richard C. Billups; John C. Todaro
- 国际申请： PCT/US2008/010473 WO 20080908
- 国际公布： WO2009/035558 WO 20090319
- 主分类号： C07D231/12
- IPC分类号： C07D231/12
摘要：
The present invention relates to a process for the production of crystalline particles of a glucagon receptor antagonist compound. The process includes the steps of generating microseeds and subjecting the microseeds to a crystallization process. The resulting crystalline particles have a mean particle size of less than about 100 mm. The present invention also provides for a pharmaceutical composition which includes the crystalline particles produced by the method described herein and a pharmaceutically acceptable carrier.
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