An optical navigation system with optical imaging of multiple inputs using a single navigation sensor. The optical navigation system includes a tactile interface device, an image sensor, and a processor. The tactile interface device facilitates a navigation input. The image sensor intermittently generates images of a surface of the tactile interface device and images of a contact navigation surface. The image sensor also generates the images of the surface of the tactile interface device exclusive of the images of the contact navigation surface. The processor is coupled to the image sensor. The processor generates a first navigation signal based on the images of the tactile interface device and generates a second navigation signal based on the images of the contact navigation surface.