Data of a transport block set is to be transmitted in a wireless communication system. The wireless communication system uses adaptive modulation and coding and has a physical layer hybrid automatic repeat request mechanism. Segmentation information for potential segmentation of the transport block set is provided. The transport block set is transmitted with a first specified modulation and coding scheme. The transport bock set is received and whether the received transport block set is determined to meet a specified quality. When the specified quality is not met, a repeat request is transmitted. The first specified modulation and coding set is changed to a second specified modulation and coding set. In response to the repeat request, the transmit block set is segmented into a plurality of segments supported by the second specified modulation and coding set in accordance with the provided segmentation information. The segments are transmitted and at least two of the segments are transmitted separately. The transmitted segments are received. The segmentation process may be applied more than once for a particular TBS transmission.