发明授权
US08236804B2 Polymorphic forms of 1-′4-(5-cyanoindol-3-yl)butyl-4-(2-carbamoylbenzofuran-5-yl)piperazine hydrochloride
有权
1-（4-氰基吲哚-3-基）丁基-4-（2-氨基甲酰基苯并呋喃-5-基）哌嗪盐酸盐的多晶型
- 专利标题： Polymorphic forms of 1-′4-(5-cyanoindol-3-yl)butyl-4-(2-carbamoylbenzofuran-5-yl)piperazine hydrochloride
- 专利标题（中）： 1-（4-氰基吲哚-3-基）丁基-4-（2-氨基甲酰基苯并呋喃-5-基）哌嗪盐酸盐的多晶型
-
申请号： US13100948申请日： 2011-05-04
-
公开(公告)号： US08236804B2公开(公告)日： 2012-08-07
- 发明人: Andreas Bathe , Bernd Helfert , Steffen Neuenfeld , Heike Kniel , Matthias Bartels , Susanne Rudolph , Henning Böttcher
- 申请人： Andreas Bathe , Bernd Helfert , Steffen Neuenfeld , Heike Kniel , Matthias Bartels , Susanne Rudolph , Henning Böttcher
- 申请人地址： DE Darmstadt
- 专利权人： Merck Patentgesellschaft
- 当前专利权人： Merck Patentgesellschaft
- 当前专利权人地址： DE Darmstadt
- 代理机构： McCarter & English, LLP
- 优先权： EP01113647 20010619
- 主分类号： A61K31/496
- IPC分类号： A61K31/496 ; C07D401/14
摘要：
The invention relates to new crystalline modifications of the hydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine, crystalline modification of the dihydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine and amorphous 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine hydrochloride which are suitable in particular for the preparation of solid medicaments for the treatment or prevention of depressive disorders, anxiety disorders, bipolar disorders, mania, dementia, substance-related disorders, sexual dysfunctions, eating disorders, obesity, fibromyalgia, sleeping disorders, psychiatric disorders, cerebral infarct, tension, for the therapy of side-effects in the treatment of hypogonadism, secondary amenorrhea, premenstrual syndrome and undesired puerperal lactation.
公开/授权文献
信息查询
IPC分类:
