- 专利标题: Anti-human IL-21 monoclonal antibodies
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申请号: US12971495申请日: 2010-12-17
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公开(公告)号: US08241629B2公开(公告)日: 2012-08-14
- 发明人: Stephen R. Jaspers , Mark W. Rixon , Stacey R. Dillon , Frederick J. Ramsdell , Cecile M. Krejsa , Eugene C. Yi
- 申请人: Stephen R. Jaspers , Mark W. Rixon , Stacey R. Dillon , Frederick J. Ramsdell , Cecile M. Krejsa , Eugene C. Yi
- 申请人地址: US WA Seattle
- 专利权人: ZymoGenetics, Inc.
- 当前专利权人: ZymoGenetics, Inc.
- 当前专利权人地址: US WA Seattle
- 代理机构: Nelson Mullins Riley & Scarborough LLP
- 代理商 Jane E. Remillard, Esq.; Jeanne M. DiGiorgio, Esq.
- 主分类号: A61K39/395
- IPC分类号: A61K39/395
摘要:
Human anti-human IL-21 monoclonal antibodies and the hybridomas that produce them are presented. Certain of these antibodies have the ability to bind native human IL-21, a mutant recombinat IL-21 protein and/or peptide regions of human IL-21. These human anti-IL-21 antibodies are useful in therapeutic treatment of autoimmune and inflammatory diseases, particularly diseases mediated by T follicular helper cells, B cells TH cells or TH17 cells.
公开/授权文献
- US20110130548A1 ANTI-HUMAN IL-21 MONOCLONAL ANTIBODIES 公开/授权日:2011-06-02