Invention Grant
- Patent Title: Microorganisms for the production of methacrylic acid
- Patent Title (中): 用于生产甲基丙烯酸的微生物
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Application No.: US12433829Application Date: 2009-04-30
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Publication No.: US08241877B2Publication Date: 2012-08-14
- Inventor: Anthony P. Burgard , Mark J. Burk , Robin E. Osterhout , Priti Pharkya
- Applicant: Anthony P. Burgard , Mark J. Burk , Robin E. Osterhout , Priti Pharkya
- Applicant Address: US CA San Diego
- Assignee: Genomatica, Inc.
- Current Assignee: Genomatica, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Jones Day
- Main IPC: C12P7/40
- IPC: C12P7/40 ; C12P7/52 ; C12N9/00 ; C12N1/20 ; C12N15/00 ; C07H21/04
Abstract:
The invention provides a non-naturally occurring microbial organism having a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The invention additionally provides a method for producing 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid. The method can include culturing a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid producing microbial organism expressing at least one exogenous nucleic acid encoding a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway enzyme in a sufficient amount and culturing under conditions and for a sufficient period of time to produce 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid.
Public/Granted literature
- US20090275096A1 MICROORGANISMS FOR THE PRODUCTION OF METHACRYLIC ACID Public/Granted day:2009-11-05
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