发明授权
US08242276B2 Methods for the preparation of N-(S)-1-azabicyclo[2.2.2]oct-3-yl-1H-indazole-3-carboxamide hydrochloride salt
有权
制备N-(S)-1-氮杂双环[2.2.2]辛-3-基-1H-吲唑-3-甲酰胺盐酸盐的方法
- 专利标题: Methods for the preparation of N-(S)-1-azabicyclo[2.2.2]oct-3-yl-1H-indazole-3-carboxamide hydrochloride salt
- 专利标题(中): 制备N-(S)-1-氮杂双环[2.2.2]辛-3-基-1H-吲唑-3-甲酰胺盐酸盐的方法
-
申请号: US13166850申请日: 2011-06-23
-
公开(公告)号: US08242276B2公开(公告)日: 2012-08-14
- 发明人: Jodie Brice , Miall Cedilote , Zhiming Dong , Pingsheng Zhang
- 申请人: Jodie Brice , Miall Cedilote , Zhiming Dong , Pingsheng Zhang
- 申请人地址: US NJ Nutley
- 专利权人: Hoffmann-La Roche Inc.
- 当前专利权人: Hoffmann-La Roche Inc.
- 当前专利权人地址: US NJ Nutley
- 代理商 George W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- 主分类号: C07D453/02
- IPC分类号: C07D453/02
摘要:
The present invention provides novel methods for preparing N—(S)-1 -azabicyclo[2.2.2]oct-3-yl-1H-indazole-3-carboxamide HCl salt 1, a nicotinic α-7 receptor ligand, that are useful for the scaled-up preparation of compound 1. Compound 1 is useful in the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain, such as for the treatment of Alzheimer's disease and schizophrenia, as well as other psychiatric and neurological disorders.
公开/授权文献
信息查询