The present invention relates to a method and apparatus of providing 2-stage ESD protection for high-speed interfaces. An aspect of the present invention is to provide an integrated multi-stage ESD/EOS protection solution for such high-speed applications. In one embodiment, the ESD protection device has multiple ESD stages integrated into a single integrated circuit package and is mounted to a printed circuit board in series with a device under protection. In another embodiment the multiple ESD stages integrated into a single integrated circuit package of the ESD protection device are coupled with a series element that isolates a 2nd stage from a 1st stage during an ESD event, thus ensuring that the 2nd stage turns on before the 1st stage, as well as provides for less current in the 2nd stage.