A method and apparatus for transmitting a signal in a wireless communication system are disclosed. The signal transmission method includes grouping a plurality of subcarriers included in a first Orthogonal Frequency Division Multiple Access (OFDMA) symbol within distributed resources into a plurality of subcarrier groups, each subcarrier group having a predetermined number of subcarriers, distributing the plurality of subcarrier groups of the first OFDMA symbol according to a first permutation pattern, transmitting data in the distributed subcarrier groups of the first OFDMA symbol, grouping a plurality of subcarriers included in a second OFDMA symbol within the distributed resources into a plurality of subcarrier groups, each subcarrier group having a predetermined number of subcarriers, distributing the plurality of subcarrier groups of the second OFDMA symbol according to a second permutation pattern, and transmitting data in the distributed subcarrier groups of the second OFDMA symbol.