发明授权
- 专利标题： Compositions and methods for modulation of LMNA expression
- 专利标题（中）： LMNA表达调控的组成和方法
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申请号： US12090847申请日： 2006-10-17
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公开(公告)号： US08258109B2公开(公告)日： 2012-09-04
- 发明人: C. Frank Bennett , Kenneth W. Dobie , Susan M. Freier , Stanley T. Crooke
- 申请人： C. Frank Bennett , Kenneth W. Dobie , Susan M. Freier , Stanley T. Crooke
- 申请人地址： US CA Carlsbad
- 专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Carlsbad
- 代理机构： Jones Day
- 国际申请： PCT/US2006/041018 WO 20061017
- 国际公布： WO2007/047913 WO 20070426
- 主分类号： C12N15/11
- IPC分类号： C12N15/11
摘要：
Disclosed herein are compounds, compositions and methods for modulating the expression of LMNA in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Further provided are methods of identifying cis splicing regulatory elements of a selected mRNA using the disclosed compounds.
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