发明授权
US08258113B2 Method for promoting angiogenesis, vascularization or vessel repair
有权
促进血管生成,血管化或血管修复的方法
- 专利标题: Method for promoting angiogenesis, vascularization or vessel repair
- 专利标题(中): 促进血管生成,血管化或血管修复的方法
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申请号: US12739876申请日: 2008-10-30
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公开(公告)号: US08258113B2公开(公告)日: 2012-09-04
- 发明人: Stefanie Dimmeler , Andreas M. Zeiher , Angelika Bonauer , Carmen Urbich
- 申请人: Stefanie Dimmeler , Andreas M. Zeiher , Angelika Bonauer , Carmen Urbich
- 申请人地址: DE Frankfurt am Main
- 专利权人: t2cure GmbH
- 当前专利权人: t2cure GmbH
- 当前专利权人地址: DE Frankfurt am Main
- 代理机构: Saliwanchik, Lloyd & Eisenschenk
- 优先权: DE102007052114 20071030
- 国际申请: PCT/DE2008/001759 WO 20081030
- 国际公布: WO2009/056116 WO 20090507
- 主分类号: C12N15/11
- IPC分类号: C12N15/11 ; C07H21/04 ; C12Q1/68
摘要:
The invention relates to a method for influencing the miR-92 expression in a cell, comprising the following steps: (a) providing a cell; and (b1) reducing the miR-92 expression in the cell in order to promote the vascularization or vessel repair by introducing an antisense molecule against miR-92 into the cell, or (b2) increasing the miR-92 expression in the cell for an inhibition of the tumor angiogenesis by introducing a construct into the cell, wherein the construct includes an expressible miR-92 sequence. Furthermore, the invention relates to a pharmaceutical composition, comprising an agent for reducing the miR-92 activity or expression in a cell in the form of an antisense molecule against miR-92, or an agent for increasing the miR-92 expression in a cell in the form of a construct for expressing miR-92.
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