发明授权
- 专利标题： Process for the preparation of temozolomide and analogs
- 专利标题（中）： 替莫唑胺和类似物的制备方法
-
申请号： US12442516申请日： 2007-09-28
-
公开(公告)号： US08258294B2公开(公告)日： 2012-09-04
- 发明人: Srinivas Laxminarayan Pathi , Dharmaraj Ramachandra Rao , Rajendra Narayanrao Kankan
- 申请人： Srinivas Laxminarayan Pathi , Dharmaraj Ramachandra Rao , Rajendra Narayanrao Kankan
- 申请人地址： IN Mumbai
- 专利权人： CIPLA Limited
- 当前专利权人： CIPLA Limited
- 当前专利权人地址： IN Mumbai
- 代理机构： Conley Rose, P.C.
- 代理商 Rodney B. Carroll
- 优先权： IN1611/MUM/2006 20060929
- 国际申请： PCT/GB2007/003726 WO 20070928
- 国际公布： WO2008/038031 WO 20080403
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; C07D233/90 ; A61K31/4188 ; A61P35/00
摘要：
A process for the preparation of compounds of formula IA, where R═CH3 (i.e. temozolomide): comprising diazotizing a compound of the formula IIA: where in R is as defined above in the presence of at least one metal halide, an acid and a source of nitrous acid, followed by conversion of acidic solution containing temozolomide. The conversion can be carried out by a liquid-liquid extraction technique in a water immiscible solvent. The temozolomide may be further purified in an acetone-water mixture.
公开/授权文献
- US20090326028A1 Process for the preparation of temozolomide and analogs 公开/授权日：2009-12-31
信息查询
