发明授权
- 专利标题: Hydroxylation of β-dicarbonyls with zirconium catalysts
- 专利标题(中): 用锆催化剂羟基化羰基
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申请号: US13048999申请日: 2011-03-16
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公开(公告)号: US08258345B2公开(公告)日: 2012-09-04
- 发明人: Albert Loren Casalnuovo
- 申请人: Albert Loren Casalnuovo
- 申请人地址: US DE Wilmington
- 专利权人: E I du Pont de Nemours and Company
- 当前专利权人: E I du Pont de Nemours and Company
- 当前专利权人地址: US DE Wilmington
- 代理商 Craig L. Hillemann
- 主分类号: C07C211/01
- IPC分类号: C07C211/01
摘要:
The present invention pertains to a process for preparing a compound of Formula I that is achiral, racemic or enantiomerically enriched at the hydroxylation center indicated by * comprising contacting a compound of Formula II with an oxidant selected from oxygen, hydrogen peroxide, peracids or alkyl hydroperoxides in the presence of a zirconium complex, wherein R1, R2 and R3 are as defined in the disclosure. This invention also pertains to zirconium complexes useful in this procedure comprising zirconium and a ligand of Formula III or its enantiomer wherein J, R6 and n are as defined in the disclosure. This invention further pertains to a compound of Formula III or its enantiomer.
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