A method and apparatus for transmitting and receiving data in a Base Station (BS) of a communication system are provided. A controller determines a location of a Mobile Station (MS), and determines a transmission/reception scheme for data transmission and reception to/from the MS according to the location of the MS. A transceiver transmits and receives data to/from the MS using the determined transmission/reception scheme. Preferably, the MS is located in any one of a cell's inner region and a cell's outer region, the cell's inner region has a radius which varies according to interference between adjacent cells, and the cell's outer region is a region defined by excepting the cell's inner region from the entire cell region.