Methods and devices are provided for deploying and applying multiple suture anchors. In one embodiment, a surgical device is provided having a shaft configured to be introduced into a body, e.g., through a scoping device, and to deliver a plurality of suture anchors, each having a suture attached thereto, into tissue, preferably without the need to remove the shaft from the body. The shaft can be configured to penetrate tissue and to deploy one or more of the suture anchors through the tissue such that the sutures extending from the deployed suture anchors extend through the tissue to allow the anchors to engage the tissue. The surgical device can also include a knotting mechanism configured to secure the sutures attached to the deployed anchors, thereby securing the anchors to the tissue.