Invention Grant
US08263094B2 Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids and preparation thereof
失效
4,5-二取代 - 氧基-2-甲基-3,6-二氧代 - 环己-1,4-二烯基烷基酯的酯及其制备
- Patent Title: Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids and preparation thereof
- Patent Title (中): 4,5-二取代 - 氧基-2-甲基-3,6-二氧代 - 环己-1,4-二烯基烷基酯的酯及其制备
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Application No.: US12236171Application Date: 2008-09-23
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Publication No.: US08263094B2Publication Date: 2012-09-11
- Inventor: Michael Fitzpatrick Wempe , Liu Deng , Stephanie Kay Clendennen , Neil Warren Boaz
- Applicant: Michael Fitzpatrick Wempe , Liu Deng , Stephanie Kay Clendennen , Neil Warren Boaz
- Applicant Address: US TN Kongsport
- Assignee: Eastman Chemical Company
- Current Assignee: Eastman Chemical Company
- Current Assignee Address: US TN Kongsport
- Agent Jennifer R. Knight
- Main IPC: A61K8/02
- IPC: A61K8/02 ; C12P33/20 ; C07D487/00
Abstract:
Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids were prepared chemically and/or enzymatically. Depending upon the ester, improved melanocyte cytotoxicity was achieved. Improved cytotoxicity characteristics are consistent with ester analogs being more physiologically compatible and less irritating to skin than their corresponding acids.
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