发明授权
- 专利标题： Substituted aminobutyric derivatives as neprilysin inhibitors
- 专利标题（中）： 取代的氨基丁酸衍生物作为内皮素抑制剂
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申请号： US12788794申请日： 2010-05-27
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公开(公告)号： US08263629B2公开(公告)日： 2012-09-11
- 发明人: Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
- 申请人： Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
- 申请人地址： CH Basel
- 专利权人： Novartis AG
- 当前专利权人： Novartis AG
- 当前专利权人地址： CH Basel
- 代理商 Sophie Binet Cross
- 主分类号： A61K31/42
- IPC分类号： A61K31/42 ; A61K31/4245 ; A61K31/41 ; C07D271/04 ; C07D271/06 ; C07D271/08 ; C07D271/10 ; C07D263/30 ; C07D261/06 ; C07D257/02
摘要：
The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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