Invention Grant
- Patent Title: Pyridazinone derivatives as PARP inhibitors
- Patent Title (中): 哒嗪酮衍生物作为PARP抑制剂
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Application No.: US12739262Application Date: 2008-11-14
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Publication No.: US08268827B2Publication Date: 2012-09-18
- Inventor: Danila Branca , Gabriella Dessole , Federica Ferrigno , Philip Jones , Olaf Kinzel , Samuele Lillini , Ester Muraglia , Giovanna Pescatore , Carsten Schultz-Fademrecht
- Applicant: Danila Branca , Gabriella Dessole , Federica Ferrigno , Philip Jones , Olaf Kinzel , Samuele Lillini , Ester Muraglia , Giovanna Pescatore , Carsten Schultz-Fademrecht
- Applicant Address: IT Pomezia, Rome
- Assignee: Istituto di Ricerche di Biologia Molecolare P. Angeletti SpA.
- Current Assignee: Istituto di Ricerche di Biologia Molecolare P. Angeletti SpA.
- Current Assignee Address: IT Pomezia, Rome
- Agent Yong Zhao; David A. Muthard; Matthew A. Leff
- Priority: GB0722401.7 20071115; GB0816707.4 20080912
- International Application: PCT/GB2008/051063 WO 20081114
- International Announcement: WO2009/063244 WO 20090522
- Main IPC: C07D401/00
- IPC: C07D401/00 ; A60K31/50
Abstract:
The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.
Public/Granted literature
- US20100261709A1 PYRIDAZINONE DERIVATIVES AS PARP INHIBITORS Public/Granted day:2010-10-14
Information query
