发明授权
US08268863B2 Disubstituted alkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
有权
二取代的烷基-8-氮杂双环[3.2.1]辛烷化合物作为μ阿片受体拮抗剂
![Disubstituted alkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists](/docs/US/2012-09-18/US08268863B2/abs.jpg.600x600.jpg)
- 专利标题： Disubstituted alkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
- 专利标题（中）： 二取代的烷基-8-氮杂双环[3.2.1]辛烷化合物作为μ阿片受体拮抗剂
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申请号： US13031873申请日： 2011-02-22
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公开(公告)号： US08268863B2公开(公告)日： 2012-09-18
- 发明人: Daisuke Roland Saito , Daniel D. Long , John R. Jacobsen
- 申请人： Daisuke Roland Saito , Daniel D. Long , John R. Jacobsen
- 申请人地址： US CA South San Francisco
- 专利权人： Theravance, Inc.
- 当前专利权人： Theravance, Inc.
- 当前专利权人地址： US CA South San Francisco
- 代理商 Jeffrey A. Hagenah; Roberta P. Saxon
- 主分类号： A01N43/42
- IPC分类号： A01N43/42 ; A61K31/44
![Disubstituted alkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists](/abs-image/US/2012/09/18/US08268863B2/abs.jpg.150x150.jpg)
摘要：
The invention provides novel 8-azabicyclo[3.2.1]octane compounds of formula (I): where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.