发明授权
- 专利标题： Quaternary alkyl ammonium bacterial efflux pump inhibitors and therapeutic uses thereof
- 专利标题（中）： 季铵烷基铵细菌外排泵抑制剂及其治疗用途
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申请号： US12116164申请日： 2008-05-06
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公开(公告)号： US08268865B2公开(公告)日： 2012-09-18
- 发明人: Tomasz Glinka , Olga Lomovskaya , Keith Bostian , David M. Wallace
- 申请人： Tomasz Glinka , Olga Lomovskaya , Keith Bostian , David M. Wallace
- 申请人地址： US CA San Diego
- 专利权人： Rempex Pharmaceuticals, Inc.
- 当前专利权人： Rempex Pharmaceuticals, Inc.
- 当前专利权人地址： US CA San Diego
- 代理机构： Knobbe, Martens, Olson & Bear LLP
- 主分类号： C07D215/38
- IPC分类号： C07D215/38 ; A61K31/04
摘要：
Disclosed are compounds having at least one quaternary alkyl ammonium functionality. The compounds inhibit bacterial efflux pump inhibitors and are used in combination with an anti-bacterial agent to treat or prevent bacterial infections. These combinations can be effective against bacterial infections that have developed resistance to anti-bacterial agents through an efflux pump mechanism.
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