Invention Grant
- Patent Title: Inhibitors
- Patent Title (中): 抑制剂
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Application No.: US13044678Application Date: 2011-03-10
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Publication No.: US08269019B2Publication Date: 2012-09-18
- Inventor: Ulrich Heiser , Ulf-Torsten Gaertner , Hans-Ulrich Demuth
- Applicant: Ulrich Heiser , Ulf-Torsten Gaertner , Hans-Ulrich Demuth
- Applicant Address: DE Halle/Saale
- Assignee: Probiodrug AG
- Current Assignee: Probiodrug AG
- Current Assignee Address: DE Halle/Saale
- Agency: SNR Denton US LLP
- Main IPC: A61K31/4184
- IPC: A61K31/4184 ; C07D235/06 ; C07D401/14
Abstract:
Novel heterocyclic derivatives as inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5). QC catalyzes the intramolecular cyclization of N-terminal glutamine residues into pyroglutamic acid (5-oxo-prolyl, pGlu*) under liberation of ammonia and the intramolecular cyclization of N-terminal glutamate residues into pyroglutamic acid under liberation of water.
Public/Granted literature
- US20110224254A1 NOVEL INHIBITORS Public/Granted day:2011-09-15
Information query
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