Invention Grant
- Patent Title: Method for diagnosing non-small cell lung carcinoma
- Patent Title (中): 诊断非小细胞肺癌的方法
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Application No.: US12063781Application Date: 2006-08-14
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Publication No.: US08273701B2Publication Date: 2012-09-25
- Inventor: David J. Robbins , Ziqiang Yuan , John A. Goetz
- Applicant: David J. Robbins , Ziqiang Yuan , John A. Goetz
- Applicant Address: US NH Hanover
- Assignee: Trustees of Dartmouth College
- Current Assignee: Trustees of Dartmouth College
- Current Assignee Address: US NH Hanover
- Agency: Licata & Tyrrell P.C.
- International Application: PCT/US2006/031685 WO 20060814
- International Announcement: WO2007/027421 WO 20070308
- Main IPC: A01N61/00
- IPC: A01N61/00
Abstract:
The present invention relates to the constitutive activity of the Hedgehog pathway in non-small cell lung carcinoma (NSCLC). A method for diagnosing NSCLC by detecting the level of a component of the Hedgehog pathway is provided, as is a method for identifying subjects that will respond positively to treatment with a Hedgehog pathway antagonist. Methods for treating subjects with cancer or cancers resistant to Hedgehog pathway antagonists are also provided.
Public/Granted literature
- US20100029580A1 Method for Diagnosing Non-Small Cell Lung Carcinoma Public/Granted day:2010-02-04
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