Invention Grant
US08273867B2 Transducible delivery of siRNA by dsRNA binding domain fusions to PTD/CPPS
有权
通过dsRNA结合域融合到PTD / CPPS的siRNA可转导递送
- Patent Title: Transducible delivery of siRNA by dsRNA binding domain fusions to PTD/CPPS
- Patent Title (中): 通过dsRNA结合域融合到PTD / CPPS的siRNA可转导递送
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Application No.: US12278739Application Date: 2007-02-09
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Publication No.: US08273867B2Publication Date: 2012-09-25
- Inventor: Steven F. Dowdy , Jehangir S. Wadia , Bryan Meade , Akiko Eguchi
- Applicant: Steven F. Dowdy , Jehangir S. Wadia , Bryan Meade , Akiko Eguchi
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Gavrilovich, Dodd & Lindsey LLP
- Agent Joseph R. Baker, Jr.
- International Application: PCT/US2007/003641 WO 20070209
- International Announcement: WO2007/095152 WO 20070823
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C07H21/02
Abstract:
The disclosure provides fusion polypeptides and constructs useful in delivering anionically charged nucleic acid molecules including diagnostics and therapeutics to a cell or subject. The fusion constructs include a protein transduction domain and a nucleic acid binding domain, or a protein transduction domain and a nucleic acid that is coated with one or more nucleic acid binding domains sufficient to neutralize an anionic charge on the nucleic acid. Also provided are methods of treating disease and disorders such as cell proliferative disorders.
Public/Granted literature
- US20090093026A1 TRANSDUCIBLE DELIVERY OF siRNA BY dsRNA BINDING DOMAIN FUSIONS TO PTD/CPPS Public/Granted day:2009-04-09
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