发明授权
- 专利标题： Crystal comprising (2R)-2-propyloctanoic acid and amine
- 专利标题（中）： 包含（2R）-2-丙基辛酸和胺的晶体
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申请号： US12872384申请日： 2010-08-31
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公开(公告)号： US08273916B2公开(公告)日： 2012-09-25
- 发明人: Tomoyuki Hasegawa , Yasufumi Kawanaka , Eiji Kasamatsu
- 申请人： Tomoyuki Hasegawa , Yasufumi Kawanaka , Eiji Kasamatsu
- 申请人地址： JP Osaka
- 专利权人： Ono Pharmaceutical Co., Ltd.
- 当前专利权人： Ono Pharmaceutical Co., Ltd.
- 当前专利权人地址： JP Osaka
- 代理机构： Sughrue Mion, PLLC
- 优先权： JP2004-134655 20040428
- 主分类号： C07B57/00
- IPC分类号： C07B57/00
摘要：
According to the present invention, crystals comprising (2R)-2-propyloctanoic acid and an amine, which can be used as bulk drugs for safely orally administrable solid preparations with keeping the pharmacological effect, are provided. Among these crystals, the crystal with dibenzylamine per se is particularly useful as bulk drug for pharmaceuticals and can be used as an intermediate to produce (2R)-2-propyloctanoic acid having an optical purity of more than 99.5% e.e. which has not been obtained.
公开/授权文献
- US20100331414A1 CRYSTAL COMPRISING (2R)-2-PROPYLOCTANOIC ACID AND AMINE 公开/授权日：2010-12-30
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