Provided are a switching circuit and a small-size high-efficiency direct current-to-direct current (DC-DC) converter for portable devices including the same. Using dynamic threshold-complementary metal oxide semiconductor (DT-CMOS) transistors having dynamic threshold voltages as a switching device, the switching circuit maintains a low threshold voltage in a normal mode to improve current drivability while reducing conduction loss, and maintains a high threshold voltage in a standby mode to minimize power consumption. When the switching circuit is employed in a DC-DC converter, power conversion efficiency can be improved by reducing conduction loss in the normal mode, and power consumption can be minimized in the standby mode. Consequently, the DC-DC converter can maximize a use time of a battery of a portable device and can be useful in power supplies of portable devices that are gradually being miniaturized.