Provided are a receiver and a method for detecting a signal in a multiple antenna system. The receiver includes a filter coefficient calculator and a signal detector. After separating a first signal portion and a second signal portion, the filter coefficient calculator calculates an MMSE filter coefficient using a Matrix Inversion Lemma such that an inverse matrix of the first signal portion has a predetermined constant value regardless of a repetition signal detection process. The signal detector detects a relevant transmission signal from an interference-removed reception signal using the MMSE filter coefficient.