Systems and methods for consumer price index determination using panel-based and point-of-sale market research data are disclosed. An example method to determine a consumer price index disclosed herein comprises obtaining panelist market research data determined by monitoring items purchased by a plurality of statistically-selected panelists, obtaining retail site market research data for items sold by a plurality of retail sites, combining the panelist market research data and the retail site market research data to determine weighted equivalent unit pricing information for each group of common items in an item stratum of the consumer price index having substantially similar attributes except for a unit amount, and determining the consumer price index using the weighted equivalent unit pricing information.