Embodiments of the hybrid tool string include coiled tubing and jointed tubing, as well as a means typically located at the connection of the coiled and jointed tubing for sealing the fluid flowpath through the bore of the hybrid tool string. Embodiments of the hybrid tool string may use a pressure-activated valve tool attached in series between the coiled tubing and the jointed tubing, which allows for sealing of the bore by application of pressure. Embodiments of the pressure-activated valve tool may use a flapper in conjunction with a sleeve to seal the bore. The novel hybrid tool string may be used to service a well.