Invention Grant
US08278263B2 Method of regulating mammalian target-of-rapamycin activity by interaction between phospholipase D and raptor
失效
通过磷脂酶D和猛禽相互作用调节哺乳动物雷帕霉素活性的方法
- Patent Title: Method of regulating mammalian target-of-rapamycin activity by interaction between phospholipase D and raptor
- Patent Title (中): 通过磷脂酶D和猛禽相互作用调节哺乳动物雷帕霉素活性的方法
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Application No.: US12374262Application Date: 2007-08-03
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Publication No.: US08278263B2Publication Date: 2012-10-02
- Inventor: Sung-Ho Ryu , Pann-Ghill Suh , Sang-Hoon Ha , Do-Hyung Kim , Il-Shin Kim , Jung-Hwan Kim , Mi-Nam Lee , Hyun-Ju Lee , Jong Heon Kim , Sung-Key Jang , Tae-Hoon Lee
- Applicant: Sung-Ho Ryu , Pann-Ghill Suh , Sang-Hoon Ha , Do-Hyung Kim , Il-Shin Kim , Jung-Hwan Kim , Mi-Nam Lee , Hyun-Ju Lee , Jong Heon Kim , Sung-Key Jang , Tae-Hoon Lee
- Applicant Address: KR Pohang
- Assignee: Postech Academy-Industry Foundation
- Current Assignee: Postech Academy-Industry Foundation
- Current Assignee Address: KR Pohang
- Agency: Marshall, Gerstein & Borun LLP
- International Application: PCT/KR2007/003753 WO 20070803
- International Announcement: WO2008/016281 WO 20080207
- Main IPC: A61K38/02
- IPC: A61K38/02
Abstract:
The present invention relates to a method of regulating mammalian target-of-rapamycin (mTOR) by regulating a phospholipase D (PLD) activity that generates a complex with mTOR. Further, the present invention also relates to a method of screening inhibitors of mTOR, and a method and a composition for treating mTOR-related metabolic diseases by inhibiting mTOR.
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