发明授权
US08278320B2 Azabicyclo[2.2.1]heptane compounds as alpha-7 nicotinic acetylcholine receptor ligands
有权
氮杂双环[2.2.1]庚烷化合物作为α-7烟碱乙酰胆碱受体配体
![Azabicyclo[2.2.1]heptane compounds as alpha-7 nicotinic acetylcholine receptor ligands](/docs/US/2012-10-02/US08278320B2/abs.jpg.600x600.jpg)
- 专利标题： Azabicyclo[2.2.1]heptane compounds as alpha-7 nicotinic acetylcholine receptor ligands
- 专利标题（中）： 氮杂双环[2.2.1]庚烷化合物作为α-7烟碱乙酰胆碱受体配体
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申请号： US12907122申请日： 2010-10-19
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公开(公告)号： US08278320B2公开(公告)日： 2012-10-02
- 发明人: Ivar M. McDonald , Robert A. Mate , James H. Cook, II , Dalton King , Richard E. Olson , Nenghui Wang , Christiana I. Iwuagwu , F. Christopher Zusi , Matthew D. Hill , Haiquan Fang , John E. Macor
- 申请人： Ivar M. McDonald , Robert A. Mate , James H. Cook, II , Dalton King , Richard E. Olson , Nenghui Wang , Christiana I. Iwuagwu , F. Christopher Zusi , Matthew D. Hill , Haiquan Fang , John E. Macor
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： US NJ Princeton
- 代理商 James Epperson
- 主分类号： A61K31/438
- IPC分类号： A61K31/438 ; A61K31/439 ; C07D471/08
![Azabicyclo[2.2.1]heptane compounds as alpha-7 nicotinic acetylcholine receptor ligands](/abs-image/US/2012/10/02/US08278320B2/abs.jpg.150x150.jpg)
摘要：
The disclosure provides compounds of formula I, including Ia, Ib, Ic, or Id, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
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