Invention Grant
- Patent Title: Cyclic amine BACE-1 inhibitors having a benzamide substituent
- Patent Title (中): 具有苯甲酰胺取代基的环胺BACE-1抑制剂
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Application No.: US12641952Application Date: 2009-12-18
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Publication No.: US08278334B2Publication Date: 2012-10-02
- Inventor: Jared N. Cumming , Ulrich Iserloh , Andrew Stamford , Corey Strickland , Johannes H. Voigt , Yusheng Wu , Ying Huang , Yan Xia , Samuel Chackalamannil , Tao Guo , Douglas W. Hobbs , Thuy X. H. Le , Jeffrey F. Lowrie , Kurt W. Saionz , Suresh D. Babu
- Applicant: Jared N. Cumming , Ulrich Iserloh , Andrew Stamford , Corey Strickland , Johannes H. Voigt , Yusheng Wu , Ying Huang , Yan Xia , Samuel Chackalamannil , Tao Guo , Douglas W. Hobbs , Thuy X. H. Le , Jeffrey F. Lowrie , Kurt W. Saionz , Suresh D. Babu
- Applicant Address: US NJ Rahway
- Assignee: Merck, Sharp & Dohme Corp.
- Current Assignee: Merck, Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Keith D. MacMillan; Gerard M. Devlin
- Main IPC: A61K31/4439
- IPC: A61K31/4439 ; A61K31/40 ; A61K31/4025 ; C07D207/12 ; C07D401/06 ; C07D403/12

Abstract:
Disclosed are compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1 is R is —C(O)—N(R27)(R28) or and the remaining variables are as defined in the specification. Also disclosed are pharmaceutical compositions comprising the compounds of formula I.Also disclosed are methods of treating cognitive or neurodegenerative diseases such as Alzheimer's disease.Also disclosed are pharmaceutical compositions and methods of treating cognitive or neurodegenerative diseases comprising the compounds of formula I in combination with a β-secretase inhibitor other than those of formula I, an HMG-CoA reductase inhibitor, a gamma-secretase inhibitor, a non-steroidal anti-inflammatory agent, an N-methyl-D-aspartate receptor antagonist, a cholinesterase inhibitor or an anti-amyloid antibody.
Public/Granted literature
- US20100152138A1 CYCLIC AMINE BACE-1 INHIBITORS HAVING A BENZAMIDE SUBSTITUENT Public/Granted day:2010-06-17
Information query
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