发明授权
US08278425B2 N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
有权
N-取代氨基亚甲基桥连双环核酸类似物
- 专利标题: N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
- 专利标题(中): N-取代氨基亚甲基桥连双环核酸类似物
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申请号: US12602074申请日: 2008-05-22
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公开(公告)号: US08278425B2公开(公告)日: 2012-10-02
- 发明人: Thazha P. Prakash , Balkrishin Bhat , Eric E. Swayze
- 申请人: Thazha P. Prakash , Balkrishin Bhat , Eric E. Swayze
- 申请人地址: US CA Carlsbad
- 专利权人: Isis Pharmaceuticals, Inc.
- 当前专利权人: Isis Pharmaceuticals, Inc.
- 当前专利权人地址: US CA Carlsbad
- 代理机构: Isis Pharmaceuticals, Inc. Patent Dept
- 国际申请: PCT/US2008/064591 WO 20080522
- 国际公布: WO2008/150729 WO 20081211
- 主分类号: C07H19/00
- IPC分类号: C07H19/00 ; C07H21/04
摘要:
Provided herein are bicyeMc nucleosides comprising a substituted amino group in the bridge, oligomeric compounds having at least one of these bicyclic nucleosides and methods of using the oligomeric compounds. The bicyclic nucleosides comprising a substituted amino group in the bridge are useful for enhancing properties of oligomeric compounds including nuclease resistance, in certain embodiments, the oligomeric compounds hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
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