发明授权
US08278425B2 N-substituted-aminomethylene bridged bicyclic nucleic acid analogs 有权
N-取代氨基亚甲基桥连双环核酸类似物

N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
摘要:
Provided herein are bicyeMc nucleosides comprising a substituted amino group in the bridge, oligomeric compounds having at least one of these bicyclic nucleosides and methods of using the oligomeric compounds. The bicyclic nucleosides comprising a substituted amino group in the bridge are useful for enhancing properties of oligomeric compounds including nuclease resistance, in certain embodiments, the oligomeric compounds hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
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