Invention Grant
US08282990B2 Method for preparing a biodegradable polymer microsphere containing a glucose-regulating peptide
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制备含有葡萄糖调节肽的可生物降解聚合物微球的方法
- Patent Title: Method for preparing a biodegradable polymer microsphere containing a glucose-regulating peptide
- Patent Title (中): 制备含有葡萄糖调节肽的可生物降解聚合物微球的方法
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Application No.: US12595434Application Date: 2008-04-18
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Publication No.: US08282990B2Publication Date: 2012-10-09
- Inventor: Hyun Hee Kwak , Ghun II Lee , Yong Man Park , Mi Kyung Son , Hi Chang Yang , Tae Hyoung Kim , Yoon Ji Kim , Byong Moon Kim , Sung Hee Lee , Soo Hyung Kang , Moohi Yoo
- Applicant: Hyun Hee Kwak , Ghun II Lee , Yong Man Park , Mi Kyung Son , Hi Chang Yang , Tae Hyoung Kim , Yoon Ji Kim , Byong Moon Kim , Sung Hee Lee , Soo Hyung Kang , Moohi Yoo
- Applicant Address: KR Seoul
- Assignee: Dong-A Pharmaceutical, Co., Ltd.
- Current Assignee: Dong-A Pharmaceutical, Co., Ltd.
- Current Assignee Address: KR Seoul
- Agency: Lucas & Mercanti, LLP
- Priority: KR10-2007-0038467 20070419
- International Application: PCT/KR2008/002216 WO 20080418
- International Announcement: WO2008/130158 WO 20081030
- Main IPC: A61K38/17
- IPC: A61K38/17 ; A61K9/14 ; B05D7/00 ; B01J13/00
Abstract:
Disclosed are biodegradable microspheres, capable of releasing a glucose-regulating peptide in a controlled manner, comprising a biodegradable polymer carrier with the glucose -regulating peptide encapsulated therein, and methods for the preparation thereof. In addition to ensuring high encapsulation efficiency and high stability of the encapsulated drug, the microspheres shows neither an initial burst effect nor incomplete release and allows the zero -order release of drugs over a prolonged period of time, thus improving the therapeutic effect of the drug.
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