- 专利标题: Carboxamide compounds and their use as calpain inhibitors
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申请号: US12940339申请日: 2010-11-05
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公开(公告)号: US08283363B2公开(公告)日: 2012-10-09
- 发明人: Helmut Mack , Andreas Kling , Katja Jantos , Achim Moeller , Wilfried Hornberger , Charles W. Hutchins
- 申请人: Helmut Mack , Andreas Kling , Katja Jantos , Achim Moeller , Wilfried Hornberger , Charles W. Hutchins
- 申请人地址: US IL Abbott Park DE Wiesbaden
- 专利权人: Abbott Laboratories,Abbott GmbH & Co. KG
- 当前专利权人: Abbott Laboratories,Abbott GmbH & Co. KG
- 当前专利权人地址: US IL Abbott Park DE Wiesbaden
- 代理机构: Michael Best & Friedrich LLP
- 代理商 Lisa V. Mueller
- 主分类号: A61P35/00
- IPC分类号: A61P35/00 ; A61P25/00 ; A61P29/00 ; A61P31/00 ; A61P9/00 ; A61P27/02 ; A61K31/425 ; A61K31/451 ; A61K31/4015 ; A61K31/4439 ; A61K31/4164 ; C07D211/40 ; C07D207/12 ; C07D401/02 ; C07D233/02 ; C07D275/03
摘要:
The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity.The carboxamide compounds are compounds of the general formula I in which R1, R2, R3a, R3b, R4, Q, Y, A and X have the meanings mentioned in the claims and the description, the tautomers thereof and the pharmaceutically suitable salts thereof. In particular, the compounds have the general formula Ia and Ib in which R1, r, R2b, R3a, R3b, R4, Y and X have the meanings mentioned in the claims, including the tautomers thereof and the pharmaceutically suitable salts thereof. Of these compounds those are preferred wherein Y is a moiety CH2—CH2, CH2—CH2—CH2, N(Ry#)—CH2, N(Ry#)—CH2—CH2 or CH═CH—CH═, each optionally having 1 or 2 H-atoms replaced with identical or different radicals Ry, wherein Ry and Ry# have the meanings mentioned in the claims.
公开/授权文献
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IPC分类:
A | 人类生活必需 |
A61 | 医学或兽医学;卫生学 |
A61P | 化合物或药物制剂的特定治疗活性 |
A61P35/00 | 抗肿瘤药 |