Invention Grant
US08283368B2 Selective ligands for the dopamine 3 (D3) receptor and methods of using the same
有权
多巴胺3（D3）受体的选择性配体及其使用方法
- Patent Title: Selective ligands for the dopamine 3 (D3) receptor and methods of using the same
- Patent Title (中): 多巴胺3（D3）受体的选择性配体及其使用方法
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Application No.: US13060306Application Date: 2009-08-27
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Publication No.: US08283368B2Publication Date: 2012-10-09
- Inventor: Shaomeng Wang , Jianyong Chen , Gregory Collins , James H. Woods , Beth Levant
- Applicant: Shaomeng Wang , Jianyong Chen , Gregory Collins , James H. Woods , Beth Levant
- Applicant Address: US MI Ann Arbor
- Assignee: The Regents of the University of Michigan
- Current Assignee: The Regents of the University of Michigan
- Current Assignee Address: US MI Ann Arbor
- Agency: Marshall, Gerstein & Borun LLP
- International Application: PCT/US2009/055169 WO 20090827
- International Announcement: WO2010/025235 WO 20100304
- Main IPC: A01N43/78
- IPC: A01N43/78 ; A61K31/425
Abstract:
Potent and selective ligands for the dopamine 3 (D3) receptor are disclosed. The D3 receptor ligands have a structural formula (I) wherein X is C═O or SO2, R1 is C1-6 alkyl, R2 is aryl, heteroaryl, aryl, —(CH2)1-3aryl, or —(CH2)1-3heteroaryl, and n is 0 or 1. Methods of using the D3 receptor ligands in the treatment of diseases and conditions wherein modulation of the D3 receptor provides a benefit also are disclosed.
Public/Granted literature
- US20110184033A1 Selective Ligands for the Dopamine 3 (D3) Receptor and Methods of using the Same Public/Granted day:2011-07-28
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