发明授权
- 专利标题： Biphenyl amides as P2X3 and P2X2/3 antagonists
- 专利标题（中）： 联苯酰胺作为P2X3和P2X2 / 3拮抗剂
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申请号： US12820577申请日： 2010-06-22
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公开(公告)号： US08283383B2公开(公告)日： 2012-10-09
- 发明人: Chris Allen Broka , Ronald Charles Hawley
- 申请人： Chris Allen Broka , Ronald Charles Hawley
- 申请人地址： US CA Palo Alto
- 专利权人： Roche Palo Alto LLC
- 当前专利权人： Roche Palo Alto LLC
- 当前专利权人地址： US CA Palo Alto
- 代理商 Robert C. Hall
- 主分类号： A61K31/015
- IPC分类号： A61K31/015
摘要：
Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted phenyl or optionally substituted pyridinyl, and R2, R3, R4, R5, R6, R7, R8 and R9 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.
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