发明授权
US08283448B2 Methods for treating viral infection using IL-28 and IL-29 cysteine mutants
有权
使用IL-28和IL-29半胱氨酸突变体治疗病毒感染的方法
- 专利标题： Methods for treating viral infection using IL-28 and IL-29 cysteine mutants
- 专利标题（中）： 使用IL-28和IL-29半胱氨酸突变体治疗病毒感染的方法
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申请号： US13190628申请日： 2011-07-26
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公开(公告)号： US08283448B2公开(公告)日： 2012-10-09
- 发明人: Kevin M. Klucher , Wayne R. Kindsvogel , Pallavur V. Sivakumar , Katherine E Henderson
- 申请人： Kevin M. Klucher , Wayne R. Kindsvogel , Pallavur V. Sivakumar , Katherine E Henderson
- 申请人地址： US WA Seattle
- 专利权人： ZymoGenetics, Inc.
- 当前专利权人： ZymoGenetics, Inc.
- 当前专利权人地址： US WA Seattle
- 代理商 Bing Hai; Brian J. Walsh
- 主分类号： C07K14/00
- IPC分类号： C07K14/00
摘要：
IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.