A method for aiming a projectile weapon may utilize an aiming device having a primary aiming mark adapted to be sighted-in at a first selected range and one or more secondary aiming marks spaced below the primary aiming mark, and includes identifying, from at least two different groups of projectiles, a projectile group corresponding to a selected projectile. An aiming adjustment for the projectile weapon is determined and effected based on the range to the target and the nominal ballistic characteristics of the identified projectile group corresponding to the selected projectile. Other methods of aiming include identifying one projectile group from two or more predetermined projectile groups based on a selected projectile. Each predetermined projectile group preferably includes two or more different projectiles, preferably of different calibers, and a projectile having ballistic characteristics that are approximately median for each such projectile group.