发明授权
US08288100B2 Methods for detecting fetal DNA in a plasma or serum sample from a pregnant woman
有权
检测孕妇血浆或血清样品中胎儿DNA的方法
- 专利标题: Methods for detecting fetal DNA in a plasma or serum sample from a pregnant woman
- 专利标题(中): 检测孕妇血浆或血清样品中胎儿DNA的方法
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申请号: US12791776申请日: 2010-06-01
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公开(公告)号: US08288100B2公开(公告)日: 2012-10-16
- 发明人: Yuk Ming Dennis Lo , Rossa Wai Kwun Chiu , Stephen Siu Chung Chim , Chunming Ding , Kwan Chee Chan , Hing Nam Ivy Wong , Ka Chun Ryan Yuen
- 申请人: Yuk Ming Dennis Lo , Rossa Wai Kwun Chiu , Stephen Siu Chung Chim , Chunming Ding , Kwan Chee Chan , Hing Nam Ivy Wong , Ka Chun Ryan Yuen
- 申请人地址: CN Hong Kong, SAR
- 专利权人: The Chinese University of Hong Kong
- 当前专利权人: The Chinese University of Hong Kong
- 当前专利权人地址: CN Hong Kong, SAR
- 代理机构: Kilpatrick Townsend & Stockton LLP
- 主分类号: C12Q1/68
- IPC分类号: C12Q1/68 ; C07H21/02 ; C07H21/04
摘要:
This application describes the discovery that, in a pregnant woman, certain genes (such as RASSF1A, APC, CASP8, RARB, SCGB3A1, DAB2IP, PTPN6, THY1, TMEFF2, and PYCARD) originated from a fetus are highly methylated, whereas the same genes of maternal origin are unmethylated. This discovery allows the easy detection of one or more of these methylated fetal genes in a biological sample from a pregnant woman, serving as a universal indicator of the presence of fetal DNA in the sample. These fetal methylation markers are particularly useful as positive controls for a non-invasive analytical process during which the quality and quantity of fetal DNA are monitored. These newly identified fetal markers can also be measured directly for diagnosis of certain pregnancy-related conditions.
公开/授权文献
- US20110143342A1 NEW FETAL METHYLATION MARKERS 公开/授权日:2011-06-16
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