发明授权
- 专利标题： Delta-tocotrienol treatment and prevention of pancreatic cancer
- 专利标题（中）： 三角生物三烯酚治疗和预防胰腺癌
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申请号： US11768373申请日： 2007-06-26
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公开(公告)号： US08288369B2公开(公告)日： 2012-10-16
- 发明人: Mokenge P. Malafa , Said M. Sebti
- 申请人： Mokenge P. Malafa , Said M. Sebti
- 申请人地址： US FL Tampa
- 专利权人： University of South Florida
- 当前专利权人： University of South Florida
- 当前专利权人地址： US FL Tampa
- 代理机构： Smith & Hopen, P.A.
- 代理商 Robert Varkonyi
- 主分类号： A61K31/355
- IPC分类号： A61K31/355 ; A61K31/513 ; A61K31/7052 ; A61K31/7105 ; A61P35/00
摘要：
Methods are disclosed for treating neoplastic disorders, such as pancreatic cancer, using tocotrienols; namely, gamma-tocotrienol and delta tocotrienol. The antitumorogenic effects of these compounds are shown both in vitro and in vivo using several human pancreatic cancer cell lines and MIA-PACA2 human pancreatic cancer cells xenografted in nude mice. Also disclosed are methods of testing the efficacy of potential chemotherapeutic agents by measuring their effect on surrogate endpoint biomarkers, such as Ki-67 and p27. Associated compounds are also disclosed.
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